The role of oxytocin in interpersonal communication of people with borderline personality disorder
pdf (English)

Jak cytować

Podlecka , M., Nowakowska-Domagała, K., Pietras, T., & Sipowicz, K. (2023). The role of oxytocin in interpersonal communication of people with borderline personality disorder. Kwartalnik Naukowy Fides Et Ratio, 54(2), 65-72. https://doi.org/10.34766/fetr.v54i2.1188
Język / Language
Słowa kluczowe

Abstrakt

The paper outlines the role of oxytocin in regulating interpersonal communication of patients with borderline personality disorder (BPD). According to the neuropeptide model of borderline disorder, changes in the regulation of the oxytocin secretion system are indicated as a potential mechanism of interpersonal deficits, which are the core of that disorder Numerous studies have confirmed the reduced level of oxytocin in this group of people. In view of that finding, in the last dozen or so years, there have been attempts at intranasal administration of oxytocin as a potential pharmacotherapy strategy dedicated to reducing the symptoms of BPD in the interpersonal area. However, the conclusions of the research in this field are not definitive to date.

https://doi.org/10.34766/fetr.v54i2.1188
pdf (English)

Bibliografia

Afinogenova, Y. et al. (2016). Low Fasting Oxytocin Levels Are Associated With Psychopathology in Anorexia Nervosa in Partial Recovery, The Journal of Clinical Psychiatry, 77(11), e1483–e1490. https://doi.org/10.4088/JCP.15m10217

Amad, A., Thomas, P. and Rerez-Rodriguez, M.M. (2015). Borderline Personality Disorder and Oxytocin: Review of Clinical Trials and Future Directions, Current Pharmaceutical Design, 21.

Bakermans-Kranenburg, M.J. and van IJzendoorn, M.H. (2013). Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy, Translational Psychiatry, 3(5), e258–e258. https://doi.org/10.1038/tp.2013.34

Bartz, J. et al. (2011). Oxytocin can hinder trust and cooperation in borderline personality disorder, Social Cognitive and Affective Neuroscience, 6(5), 556–563. https://doi.org/10.1093/scan/nsq085

Berenson, K.R. et al. (2018). Identification of mental states and interpersonal functioning in borderline personality disorder., Personality Disorders: Theory, Research, and Treatment, 9(2), 172–181. https://doi.org/10.1037/per0000228

Bertsch, K. et al. (2013). Oxytocin and Reduction of Social Threat Hypersensitivity in Women With Borderline Personality Disorder, American Journal of Psychiatry, 170(10), 1169–1177. https://doi.org/10.1176/appi.ajp.2013.13020263

Bosch, O.J. et al. (2016). Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles, Psychoneuroendocrinology, 64, 66–78. https://doi.org/10.1016/j.psyneuen.2015.11.011

Botter, L. et al. (2021). Impact of borderline personality disorder traits on the association between age and health-related quality of life: A cohort study in the general population, European Psychiatry, 64(1), e33. https://doi.org/10.1192/j.eurpsy.2021.27

Brüne, M. et al. (2013). Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder, Human Psychopharmacology: Clinical and Experimental, 28(6), 552–561. https://doi.org/10.1002/hup.2343

Brüne, M. et al. (2015a). Nonverbal Communication of Patients With Borderline Personality Disorder During Clinical Interviews, Journal of Nervous & Mental Disease, 203(2), 107–111. https://doi.org/10.1097/NMD.0000000000000240

Brüne, M. et al. (2015b). Nonverbal Communication of Patients With Borderline Personality Disorder During Clinical Interviews, Journal of Nervous & Mental Disease, 203(2), 107–111. https://doi.org/10.1097/NMD.0000000000000240

Brüne, M. (2016). On the role of oxytocin in borderline personality disorder, British Journal of Clinical Psychology, 55(3), 287–304. https://doi.org/10.1111/bjc.12100

Carrasco, J.L. et al. (2020). Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder, Acta Psychiatrica Scandinavica, 142(4), 319–325. https://doi.org/10.1111/acps.13222

Davis, M.C. et al. (2014). Oxytocin-Augmented Social Cognitive Skills Training in Schizophrenia, Neuropsychopharmacology, 39(9), 2070–2077. https://doi.org/10.1038/npp.2014.68

Doering, S. (2019). Borderline Personality Disorder in Patients With Medical Illness: A Review of Assessment, Prevalence, and Treatment Options, Psychosomatic Medicine, 81(7), 584–594. https://doi.org/10.1097/PSY.0000000000000724

Domes, G. et al. (2007). Oxytocin Improves “Mind-Reading” in Humans, Biological Psychiatry, 61(6), 731–733. https://doi.org/10.1016/j.biopsych.2006.07.015

Domes, G. et al. (2014). Oxytocin Promotes Facial Emotion Recognition and Amygdala Reactivity in Adults with Asperger Syndrome, Neuropsychopharmacology, 39(3), 698–706. https://doi.org/10.1038/npp.2013.254

De Dreu, C.K.W. et al. (2010). The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans, Science, 328(5984), 1408–1411. https://doi.org/10.1126/science.1189047

Ebert, A. et al. (2013). Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma, Social Neuroscience, 8(4), 305–313. https://doi.org/10.1080/17470919.2013.807301.

Ebert, A. et al. (2018). Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder, Depression and Anxiety, 35(1), 50–57. https://doi.org/10.1002/da.22683

Eckstein, M. and Hurlemann, R. (2013). Oxytozin, Der Nervenarzt, 84(11), 1321–1328. https://doi.org/10.1007/s00115-013-3832-6

Ellis, B.J. et al. (2021). Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation, Clinical Psychology Review, 86, 101985. https://doi.org/10.1016/j.cpr.2021.101985

Ellison, W.D. et al. (2018). Community and Clinical Epidemiology of Borderline Personality Disorder, Psychiatric Clinics of North America, 41(4), 561–573. https://doi.org/10.1016/j.psc.2018.07.008

Evans, S., Shergill, S.S. and Averbeck, B.B. (2010). Oxytocin Decreases Aversion to Angry Faces in an Associative Learning Task, Neuropsychopharmacology, 35(13), 2502–2509. https://doi.org/10.1038/npp.2010.110

Fonagy, et al. (2013). Przywiązanie a patologia osobowości, in J. Clarkin, Fonagy, and G. Gabbard (eds). Psychoterapia psychodynamiczna zaburzeń osobowości. Kraków: Wydawnictwo Uniwersytetu Jagiellońskiego, 61–119.

Fonagy, and Bateman, A.W. (2007). Mentalizing and borderline personality disorder, Journal of Mental Health, 16(1), 83–101. https://doi.org/10.1080/09638230601182045

Fonagy, P., Luyten, and Strathearn, L. (2011). Borderline personality disorder, mentalization, and the neurobiology of attachment, Infant Mental Health Journal, 32(1), 47–69. https://doi.org/10.1002/imhj.20283

Groppe, S.E. et al. (2013). Oxytocin Influences Processing of Socially Relevant Cues in the Ventral Tegmental Area of the Human Brain, Biological Psychiatry, 74(3), 172–179. https://doi.org/10.1016/j.biopsych.2012.12.023

Gunderson, J. and Links, (2014). Handbook of Good Psychiatric Management for Borderline Personality Disorder. Washington/London: American Psychiatric Publishing.

Gunderson, J.G. and Lyons-Ruth, K. (2008). BPDs Interpersonal Hypersensitivity Phenotype: A Gene-Environment-Developmental Model, Journal of Personality Disorders, 22(1), 22–41. https://doi.org/10.1521/pedi.2008.22.1.22

Heinrichs, M. et al. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress, Biological Psychiatry, 54(12), 1389–1398. https://doi.org/10.1016/S0006-3223(03)00465-7

Herpertz, S.C. and Bertsch, K. (2015). A New Perspective on the Pathophysiology of Borderline Personality Disorder: A Model of the Role of Oxytocin, American Journal of Psychiatry, 172(9), 840–851. https://doi.org/10.1176/appi.ajp.2015.15020216

Hopwood, C.J., Schade, N. and Pincus, A.L. (2014). A Contemporary Interpersonal Model of Borderline Personality Development, in Handbook of Borderline Personality Disorder in Children and Adolescents. New York, NY: Springer New York, 293–310. https://doi.org/10.1007/978-1-4939-0591-1_20

Jobst, A. et al. (2016). Lower Oxytocin Plasma Levels in Borderline Patients with Unresolved Attachment Representations, Frontiers in Human Neuroscience, 10. https://doi.org/10.3389/fnhum.2016.00125.

Kartal, F. et al. (2022). The Relationship Between the Oxytocin Level and Rejection Sensitivity, Childhood Traumas, and Attachment Styles in Borderline Personality Disorder, Psychiatry Investigation, 19(3), 239–246. https://doi.org/10.30773/pi.2021.0358

Keech, B., Crowe, S. and Hocking, D.R. (2018). Intranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis, Psychoneuroendocrinology, 87, 9–19. https://doi.org/10.1016/j.psyneuen.2017.09.022

Kosfeld, M. et al. (2005). Oxytocin increases trust in humans, Nature, 435(7042), 673–676. https://doi.org/10.1038/nature03701

Kumsta, R. and Heinrichs, M. (2013). Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system, Current Opinion in Neurobiology, 23(1), 11–16. https://doi.org/10.1016/j.conb.2012.09.004

Labuschagne, I. et al. (2010). Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder, Neuropsychopharmacology, 35(12), 2403–2413. https://doi.org/10.1038/npp.2010.123.

Lancaster, K. et al. (2015). Plasma oxytocin explains individual differences in neural substrates of social perception, Frontiers in Human Neuroscience, 9. https://doi.org/10.3389/fnhum.2015.00132

Lazarus, S.A. et al. (2014). Interpersonal functioning in borderline personality disorder: A systematic review of behavioral and laboratory-based assessments, Clinical Psychology Review, 34(3), 193–205. https://doi.org/10.1016/j.cpr.2014.01.007

Lee, H.-J. et al. (2009). Oxytocin: The Great Facilitator of Life, Progress in Neurobiology. https://doi.org/10.1016/j.pneurobio.2009.04.001

MacDonald, K. and Feifel, D. (2012). Oxytocin in schizophrenia: a review of evidence for its therapeutic effects, Acta Neuropsychiatrica, 24(3), 130–146. https://doi.org/10.1111/j.1601-5215.2011.00634.x

Marsh, N. et al. (2021). Oxytocin and the Neurobiology of Prosocial Behavior, The Neuroscientist, 27(6), 604–619. https://doi.org/10.1177/1073858420960111

Marszał, M. (2015). Mentalizacja w kontekście przywiązania. Warszawa: Diffin.

Meyer-Lindenberg, A. et al. (2011). Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine, Nature Reviews Neuroscience, 12(9), 524–538. https://doi.org/10.1038/nrn3044

Paris, J. (2010). Effectiveness of Different Psychotherapy Approaches in the Treatment of Borderline Personality Disorder, Current Psychiatry Reports, 12(1), 56–60. https://doi.org/10.1007/s11920-009-0083-0

Ramseyer, F. et al. (2020). Exploring nonverbal synchrony in borderline personality disorder: A double-blind placebo-controlled study using oxytocin, British Journal of Clinical Psychology, 59(2), 186–207. https://doi.org/10.1111/bjc.12240

Reijnen, A., Geuze, E. and Vermetten, E. (2017). Individual variation in plasma oxytocin and vasopressin levels in relation to the development of combat-related PTSD in a large military cohort, Journal of Psychiatric Research, 94, 88–95. https://doi.org/10.1016/j.jpsychires.2017.06.010

Reiner, I. et al. (2015). Methylation of the oxytocin receptor gene in clinically depressed patients compared to controls: The role of OXTR rs53576 genotype, Journal of Psychiatric Research, 65, 9–15. https://doi.org/10.1016/j.jpsychires.2015.03.012

Ripoll, L.H. (2013). Psychopharmacologic treatment of borderline personality disorder, Dialogues in Clinical Neuroscience, 15(2), 213–224. https://doi.org/10.31887/DCNS.2013.15.2/lripoll

Roisman, G.I. et al. (2013). Molecular-genetic correlates of infant attachment: A cautionary tale, Attachment & Human Development, 15(4), 384–406. https://doi.org/10.1080/14616734.2013.768790

Ross, H.E. and Young, L.J. (2009). Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior, Frontiers in Neuroendocrinology, 30(4), 534–547. https://doi.org/10.1016/j.yfrne.2009.05.004

Rutigliano, G. et al. (2016). Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis, Psychiatry Research, 241, 207–220. https://doi.org/10.1016/j.psychres.2016.04.117

Scheele, D. et al. (2014). An Oxytocin-Induced Facilitation of Neural and Emotional Responses to Social Touch Correlates Inversely with Autism Traits, Neuropsychopharmacology, 39(9), 2078–2085. https://doi.org/10.1038/npp.2014.78

Schneiderman, I. et al. (2014). Cumulative risk on the oxytocin receptor gene ( OXTR ). underpins empathic communication difficulties at the first stages of romantic love, Social Cognitive and Affective Neuroscience, 9(10), 1524–1529. https://doi.org/10.1093/scan/nst142

Seltzer, L.J. et al. (2014). Stress-Induced Elevation of Oxytocin in Maltreated Children: Evolution, Neurodevelopment, and Social Behavior, Child Development, 85(2), 501–512. https://doi.org/10.1111/cdev.12136

Shah, R. and Zanarini, M.C. (2018). Comorbidity of Borderline Personality Disorder, Psychiatric Clinics of North America, 41(4), 583–593. https://doi.org/10.1016/j.psc.2018.07.009

Shamay-Tsoory, S.G. et al. (2009). Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating), Biological Psychiatry, 66(9), 864–870. https://doi.org/10.1016/j.biopsych.2009.06.009

Shorey, H.S. and Snyder, C.R. (2006). The Role of Adult Attachment Styles in Psychopathology and Psychotherapy Outcomes, Review of General Psychology, 10(1), 1–20. https://doi.org/10.1037/1089-2680.10.1.1

Siever, L.J. and Weinstein, L.N. (2009). The Neurobiology of Personality Disorders: Implications for Psychoanalysis, Journal of the American Psychoanalytic Association, 57(2), 361–398. https://doi.org/10.1177/0003065109333502

Simeon, D. et al. (2011). Oxytocin administration attenuates stress reactivity in borderline personality disorder: A pilot study, Psychoneuroendocrinology, 36(9), 1418–1421. https://doi.org/10.1016/j.psyneuen.2011.03.013

Stanley, B. and Siever, L.J. (2010). The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model, American Journal of Psychiatry, 167(1), 24–39. https://doi.org/10.1176/appi.ajp.2009.09050744

Stoffers, J. et al. (2010). Pharmacological interventions for borderline personality disorder, Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD005653.pub2.

Striepens, N. et al. (2011). Prosocial effects of oxytocin and clinical evidence for its therapeutic potential, Frontiers in Neuroendocrinology, 32(4), 426–450. https://doi.org/10.1016/j.yfrne.2011.07.001

Striepens, N. et al. (2012). Oxytocin facilitates protective responses to aversive social stimuli in males, Proceedings of the National Academy of Sciences, 109(44), 18144–18149. https://doi.org/10.1073/pnas.1208852109

Tomko, R.L. et al. (2014). Characteristics of Borderline Personality Disorder in a Community Sample: Comorbidity, Treatment Utilization, and General Functioning, Journal of Personality Disorders, 28(5), 734–750. https://doi.org/10.1521/pedi_2012_26_093

Turan, T. et al. (2013). May oxytocin be a trait marker for bipolar disorder?, Psychoneuroendocrinology, 38(12), 2890–2896. https://doi.org/10.1016/j.psyneuen.2013.07.017

Vancova, Z. (2021). Potential Therapeutic Possibility of Oxytocin for Borderline Personality Disorder, Psychiatric Annals, 51(3), 141–146. https://doi.org/10.3928/00485713-20210208-01

Wciórka, J., Pużyński, S. (2022). Klasyfikacja zaburzeń psychicznych i zaburzeń zachowania w ICD-10. Badawcze kryteria diagnostyczne. Vesalius.

Weisman, O. et al. (2013). Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety, Psychoneuroendocrinology, 38(5), 694–701. https://doi.org/10.1016/j.psyneuen.2012.08.011

Zanarini, M.C. et al. (2007). The Subsyndromal Phenomenology of Borderline Personality Disorder: A 10-Year Follow-Up Study, American Journal of Psychiatry, 164(6), 929–935. https://doi.org/10.1176/ajp.2007.164.6.929

Internet sources:

https://icd.who.int/browse10/2019/en#/F60.3, access: 30.05.2023

https://icd.who.int/browse11/l-m/en#/http%3a%2f%2fid.who.int%2ficd%2fentity%2f1128733473, access: 30.05.2023

##plugins.generic.usageStats.downloads##

##plugins.generic.usageStats.noStats##