Słowa kluczowe
borderline
model neuropeptydowy
zaburzenia interpersonalne
Jak cytować
Abstrakt
W niniejszym artykule zarysowano rolę oksytocyny w regulowaniu komunikacji interpersonalnej pacjentów z zaburzeniem osobowości borderline (ZOB) (borderline personality disorder BPD). Zgodnie z neuropeptydowym modelem zaburzenia borderline wskazuje się, iż zmiany w regulacji systemu wydzielania oksytocyny stanowią potencjalny mechanizm deficytów interpersonalnych, będących rdzeniem owego zaburzenia Liczne badania potwierdzają, iż poziom oksytocyny w tejże grupie osób jest obniżony. W związku z tym w przeciągu ostatnich kilkunastu lat pojawiły się próby donosowego podawania oksytocyny jako potencjalnej strategii farmakoterapii dedykowanej redukcji objawów ZOB w obszarze interpersonalnym. Wnioski płynące z dotychczasowych badań w tym obszarze nie są jednak w pełni konkluzywne.
Bibliografia
Afinogenova, Y. et al. (2016). Low Fasting Oxytocin Levels Are Associated With Psychopathology in Anorexia Nervosa in Partial Recovery, The Journal of Clinical Psychiatry, 77(11), e1483–e1490. https://doi.org/10.4088/JCP.15m10217
Amad, A., Thomas, P. and Rerez-Rodriguez, M.M. (2015). Borderline Personality Disorder and Oxytocin: Review of Clinical Trials and Future Directions, Current Pharmaceutical Design, 21.
Bakermans-Kranenburg, M.J. and van IJzendoorn, M.H. (2013). Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy, Translational Psychiatry, 3(5), e258–e258. https://doi.org/10.1038/tp.2013.34
Bartz, J. et al. (2011). Oxytocin can hinder trust and cooperation in borderline personality disorder, Social Cognitive and Affective Neuroscience, 6(5), 556–563. https://doi.org/10.1093/scan/nsq085
Berenson, K.R. et al. (2018). Identification of mental states and interpersonal functioning in borderline personality disorder., Personality Disorders: Theory, Research, and Treatment, 9(2), 172–181. https://doi.org/10.1037/per0000228
Bertsch, K. et al. (2013). Oxytocin and Reduction of Social Threat Hypersensitivity in Women With Borderline Personality Disorder, American Journal of Psychiatry, 170(10), 1169–1177. https://doi.org/10.1176/appi.ajp.2013.13020263
Bosch, O.J. et al. (2016). Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles, Psychoneuroendocrinology, 64, 66–78. https://doi.org/10.1016/j.psyneuen.2015.11.011
Botter, L. et al. (2021). Impact of borderline personality disorder traits on the association between age and health-related quality of life: A cohort study in the general population, European Psychiatry, 64(1), e33. https://doi.org/10.1192/j.eurpsy.2021.27
Brüne, M. et al. (2013). Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder, Human Psychopharmacology: Clinical and Experimental, 28(6), 552–561. https://doi.org/10.1002/hup.2343
Brüne, M. et al. (2015a). Nonverbal Communication of Patients With Borderline Personality Disorder During Clinical Interviews, Journal of Nervous & Mental Disease, 203(2), 107–111. https://doi.org/10.1097/NMD.0000000000000240
Brüne, M. et al. (2015b). Nonverbal Communication of Patients With Borderline Personality Disorder During Clinical Interviews, Journal of Nervous & Mental Disease, 203(2), 107–111. https://doi.org/10.1097/NMD.0000000000000240
Brüne, M. (2016). On the role of oxytocin in borderline personality disorder, British Journal of Clinical Psychology, 55(3), 287–304. https://doi.org/10.1111/bjc.12100
Carrasco, J.L. et al. (2020). Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder, Acta Psychiatrica Scandinavica, 142(4), 319–325. https://doi.org/10.1111/acps.13222
Davis, M.C. et al. (2014). Oxytocin-Augmented Social Cognitive Skills Training in Schizophrenia, Neuropsychopharmacology, 39(9), 2070–2077. https://doi.org/10.1038/npp.2014.68
Doering, S. (2019). Borderline Personality Disorder in Patients With Medical Illness: A Review of Assessment, Prevalence, and Treatment Options, Psychosomatic Medicine, 81(7), 584–594. https://doi.org/10.1097/PSY.0000000000000724
Domes, G. et al. (2007). Oxytocin Improves “Mind-Reading” in Humans, Biological Psychiatry, 61(6), 731–733. https://doi.org/10.1016/j.biopsych.2006.07.015
Domes, G. et al. (2014). Oxytocin Promotes Facial Emotion Recognition and Amygdala Reactivity in Adults with Asperger Syndrome, Neuropsychopharmacology, 39(3), 698–706. https://doi.org/10.1038/npp.2013.254
De Dreu, C.K.W. et al. (2010). The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans, Science, 328(5984), 1408–1411. https://doi.org/10.1126/science.1189047
Ebert, A. et al. (2013). Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma, Social Neuroscience, 8(4), 305–313. https://doi.org/10.1080/17470919.2013.807301.
Ebert, A. et al. (2018). Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder, Depression and Anxiety, 35(1), 50–57. https://doi.org/10.1002/da.22683
Eckstein, M. and Hurlemann, R. (2013). Oxytozin, Der Nervenarzt, 84(11), 1321–1328. https://doi.org/10.1007/s00115-013-3832-6
Ellis, B.J. et al. (2021). Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation, Clinical Psychology Review, 86, 101985. https://doi.org/10.1016/j.cpr.2021.101985
Ellison, W.D. et al. (2018). Community and Clinical Epidemiology of Borderline Personality Disorder, Psychiatric Clinics of North America, 41(4), 561–573. https://doi.org/10.1016/j.psc.2018.07.008
Evans, S., Shergill, S.S. and Averbeck, B.B. (2010). Oxytocin Decreases Aversion to Angry Faces in an Associative Learning Task, Neuropsychopharmacology, 35(13), 2502–2509. https://doi.org/10.1038/npp.2010.110
Fonagy, et al. (2013). Przywiązanie a patologia osobowości, in J. Clarkin, Fonagy, and G. Gabbard (eds). Psychoterapia psychodynamiczna zaburzeń osobowości. Kraków: Wydawnictwo Uniwersytetu Jagiellońskiego, 61–119.
Fonagy, and Bateman, A.W. (2007). Mentalizing and borderline personality disorder, Journal of Mental Health, 16(1), 83–101. https://doi.org/10.1080/09638230601182045
Fonagy, P., Luyten, and Strathearn, L. (2011). Borderline personality disorder, mentalization, and the neurobiology of attachment, Infant Mental Health Journal, 32(1), 47–69. https://doi.org/10.1002/imhj.20283
Groppe, S.E. et al. (2013). Oxytocin Influences Processing of Socially Relevant Cues in the Ventral Tegmental Area of the Human Brain, Biological Psychiatry, 74(3), 172–179. https://doi.org/10.1016/j.biopsych.2012.12.023
Gunderson, J. and Links, (2014). Handbook of Good Psychiatric Management for Borderline Personality Disorder. Washington/London: American Psychiatric Publishing.
Gunderson, J.G. and Lyons-Ruth, K. (2008). BPDs Interpersonal Hypersensitivity Phenotype: A Gene-Environment-Developmental Model, Journal of Personality Disorders, 22(1), 22–41. https://doi.org/10.1521/pedi.2008.22.1.22
Heinrichs, M. et al. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress, Biological Psychiatry, 54(12), 1389–1398. https://doi.org/10.1016/S0006-3223(03)00465-7
Herpertz, S.C. and Bertsch, K. (2015). A New Perspective on the Pathophysiology of Borderline Personality Disorder: A Model of the Role of Oxytocin, American Journal of Psychiatry, 172(9), 840–851. https://doi.org/10.1176/appi.ajp.2015.15020216
Hopwood, C.J., Schade, N. and Pincus, A.L. (2014). A Contemporary Interpersonal Model of Borderline Personality Development, in Handbook of Borderline Personality Disorder in Children and Adolescents. New York, NY: Springer New York, 293–310. https://doi.org/10.1007/978-1-4939-0591-1_20
Jobst, A. et al. (2016). Lower Oxytocin Plasma Levels in Borderline Patients with Unresolved Attachment Representations, Frontiers in Human Neuroscience, 10. https://doi.org/10.3389/fnhum.2016.00125.
Kartal, F. et al. (2022). The Relationship Between the Oxytocin Level and Rejection Sensitivity, Childhood Traumas, and Attachment Styles in Borderline Personality Disorder, Psychiatry Investigation, 19(3), 239–246. https://doi.org/10.30773/pi.2021.0358
Keech, B., Crowe, S. and Hocking, D.R. (2018). Intranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis, Psychoneuroendocrinology, 87, 9–19. https://doi.org/10.1016/j.psyneuen.2017.09.022
Kosfeld, M. et al. (2005). Oxytocin increases trust in humans, Nature, 435(7042), 673–676. https://doi.org/10.1038/nature03701
Kumsta, R. and Heinrichs, M. (2013). Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system, Current Opinion in Neurobiology, 23(1), 11–16. https://doi.org/10.1016/j.conb.2012.09.004
Labuschagne, I. et al. (2010). Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder, Neuropsychopharmacology, 35(12), 2403–2413. https://doi.org/10.1038/npp.2010.123.
Lancaster, K. et al. (2015). Plasma oxytocin explains individual differences in neural substrates of social perception, Frontiers in Human Neuroscience, 9. https://doi.org/10.3389/fnhum.2015.00132
Lazarus, S.A. et al. (2014). Interpersonal functioning in borderline personality disorder: A systematic review of behavioral and laboratory-based assessments, Clinical Psychology Review, 34(3), 193–205. https://doi.org/10.1016/j.cpr.2014.01.007
Lee, H.-J. et al. (2009). Oxytocin: The Great Facilitator of Life, Progress in Neurobiology. https://doi.org/10.1016/j.pneurobio.2009.04.001
MacDonald, K. and Feifel, D. (2012). Oxytocin in schizophrenia: a review of evidence for its therapeutic effects, Acta Neuropsychiatrica, 24(3), 130–146. https://doi.org/10.1111/j.1601-5215.2011.00634.x
Marsh, N. et al. (2021). Oxytocin and the Neurobiology of Prosocial Behavior, The Neuroscientist, 27(6), 604–619. https://doi.org/10.1177/1073858420960111
Marszał, M. (2015). Mentalizacja w kontekście przywiązania. Warszawa: Diffin.
Meyer-Lindenberg, A. et al. (2011). Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine, Nature Reviews Neuroscience, 12(9), 524–538. https://doi.org/10.1038/nrn3044
Paris, J. (2010). Effectiveness of Different Psychotherapy Approaches in the Treatment of Borderline Personality Disorder, Current Psychiatry Reports, 12(1), 56–60. https://doi.org/10.1007/s11920-009-0083-0
Ramseyer, F. et al. (2020). Exploring nonverbal synchrony in borderline personality disorder: A double-blind placebo-controlled study using oxytocin, British Journal of Clinical Psychology, 59(2), 186–207. https://doi.org/10.1111/bjc.12240
Reijnen, A., Geuze, E. and Vermetten, E. (2017). Individual variation in plasma oxytocin and vasopressin levels in relation to the development of combat-related PTSD in a large military cohort, Journal of Psychiatric Research, 94, 88–95. https://doi.org/10.1016/j.jpsychires.2017.06.010
Reiner, I. et al. (2015). Methylation of the oxytocin receptor gene in clinically depressed patients compared to controls: The role of OXTR rs53576 genotype, Journal of Psychiatric Research, 65, 9–15. https://doi.org/10.1016/j.jpsychires.2015.03.012
Ripoll, L.H. (2013). Psychopharmacologic treatment of borderline personality disorder, Dialogues in Clinical Neuroscience, 15(2), 213–224. https://doi.org/10.31887/DCNS.2013.15.2/lripoll
Roisman, G.I. et al. (2013). Molecular-genetic correlates of infant attachment: A cautionary tale, Attachment & Human Development, 15(4), 384–406. https://doi.org/10.1080/14616734.2013.768790
Ross, H.E. and Young, L.J. (2009). Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior, Frontiers in Neuroendocrinology, 30(4), 534–547. https://doi.org/10.1016/j.yfrne.2009.05.004
Rutigliano, G. et al. (2016). Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis, Psychiatry Research, 241, 207–220. https://doi.org/10.1016/j.psychres.2016.04.117
Scheele, D. et al. (2014). An Oxytocin-Induced Facilitation of Neural and Emotional Responses to Social Touch Correlates Inversely with Autism Traits, Neuropsychopharmacology, 39(9), 2078–2085. https://doi.org/10.1038/npp.2014.78
Schneiderman, I. et al. (2014). Cumulative risk on the oxytocin receptor gene ( OXTR ). underpins empathic communication difficulties at the first stages of romantic love, Social Cognitive and Affective Neuroscience, 9(10), 1524–1529. https://doi.org/10.1093/scan/nst142
Seltzer, L.J. et al. (2014). Stress-Induced Elevation of Oxytocin in Maltreated Children: Evolution, Neurodevelopment, and Social Behavior, Child Development, 85(2), 501–512. https://doi.org/10.1111/cdev.12136
Shah, R. and Zanarini, M.C. (2018). Comorbidity of Borderline Personality Disorder, Psychiatric Clinics of North America, 41(4), 583–593. https://doi.org/10.1016/j.psc.2018.07.009
Shamay-Tsoory, S.G. et al. (2009). Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating), Biological Psychiatry, 66(9), 864–870. https://doi.org/10.1016/j.biopsych.2009.06.009
Shorey, H.S. and Snyder, C.R. (2006). The Role of Adult Attachment Styles in Psychopathology and Psychotherapy Outcomes, Review of General Psychology, 10(1), 1–20. https://doi.org/10.1037/1089-2680.10.1.1
Siever, L.J. and Weinstein, L.N. (2009). The Neurobiology of Personality Disorders: Implications for Psychoanalysis, Journal of the American Psychoanalytic Association, 57(2), 361–398. https://doi.org/10.1177/0003065109333502
Simeon, D. et al. (2011). Oxytocin administration attenuates stress reactivity in borderline personality disorder: A pilot study, Psychoneuroendocrinology, 36(9), 1418–1421. https://doi.org/10.1016/j.psyneuen.2011.03.013
Stanley, B. and Siever, L.J. (2010). The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model, American Journal of Psychiatry, 167(1), 24–39. https://doi.org/10.1176/appi.ajp.2009.09050744
Stoffers, J. et al. (2010). Pharmacological interventions for borderline personality disorder, Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD005653.pub2.
Striepens, N. et al. (2011). Prosocial effects of oxytocin and clinical evidence for its therapeutic potential, Frontiers in Neuroendocrinology, 32(4), 426–450. https://doi.org/10.1016/j.yfrne.2011.07.001
Striepens, N. et al. (2012). Oxytocin facilitates protective responses to aversive social stimuli in males, Proceedings of the National Academy of Sciences, 109(44), 18144–18149. https://doi.org/10.1073/pnas.1208852109
Tomko, R.L. et al. (2014). Characteristics of Borderline Personality Disorder in a Community Sample: Comorbidity, Treatment Utilization, and General Functioning, Journal of Personality Disorders, 28(5), 734–750. https://doi.org/10.1521/pedi_2012_26_093
Turan, T. et al. (2013). May oxytocin be a trait marker for bipolar disorder?, Psychoneuroendocrinology, 38(12), 2890–2896. https://doi.org/10.1016/j.psyneuen.2013.07.017
Vancova, Z. (2021). Potential Therapeutic Possibility of Oxytocin for Borderline Personality Disorder, Psychiatric Annals, 51(3), 141–146. https://doi.org/10.3928/00485713-20210208-01
Wciórka, J., Pużyński, S. (2022). Klasyfikacja zaburzeń psychicznych i zaburzeń zachowania w ICD-10. Badawcze kryteria diagnostyczne. Vesalius.
Weisman, O. et al. (2013). Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety, Psychoneuroendocrinology, 38(5), 694–701. https://doi.org/10.1016/j.psyneuen.2012.08.011
Zanarini, M.C. et al. (2007). The Subsyndromal Phenomenology of Borderline Personality Disorder: A 10-Year Follow-Up Study, American Journal of Psychiatry, 164(6), 929–935. https://doi.org/10.1176/ajp.2007.164.6.929
Internet sources:
https://icd.who.int/browse10/2019/en#/F60.3, access: 30.05.2023
https://icd.who.int/browse11/l-m/en#/http%3a%2f%2fid.who.int%2ficd%2fentity%2f1128733473, access: 30.05.2023