Jak cytować
Ruta, H., Kajdy, A., & Maksym, R. (2018). Znaczenie metabolizmu kwasu foliowego dla płodności. Kwartalnik Naukowy Fides Et Ratio, 35(3), 92-101. Pobrano z https://fidesetratio.com.pl/ojs/index.php/FetR/article/view/526
Język / Language
Słowa kluczowe
Abstrakt
Kwas foliowy ma kluczowe znaczenie dla szeregu procesów fizjologicznych związanych z prokreacją w organizmie kobiety i mężczyzny. Właściwe działanie folianów w organizmie kobiecym w okresie przedkoncepcyjnym, podczas ciąży oraz karmienia piersią jest warunkiem prawidłowego rozwoju płodu i noworodka. Są to okresy zwiększonego zapotrzebowania na kwas foliowy. Biorąc udział w syntezie DNA i procesie podziału komórkowego, kwas foliowy jest szczególne istotny dla szybko dzielących się komórek, w tym w szczególności dla procesu embriogenezy i spermatogenezy. Niedostateczna podaż oraz zaburzenia metabolizmu folianów mogą skutkować obniżoną płodnością, powikłaniami ciąży oraz wadami u płodu. Szerokie populacyjne rozpowszechnienie polimorfizmów genetycznych, dotyczących genów szlaku metabolizmu kwasu foliowego i niedobory dietetyczne sprawiają, że właściwa suplementacja stanowi istotny warunek opieki nad zdrowiem prokreacyjnym.
Bibliografia
Bagley P.J., Selhub J. (1998), A common mutation in the in the methylenetetrahydrotefolate reductase gene is associated with an accumulation of non-methylated tetrahydrofolate in red blood cells. Proceedings of the National Academy of Science, Oct 27;95(22): 13217-20.
Bailey L. B., Gregory J. F. (1999), Folate metabolism and requirements, The Journal of Nutrition, 129, 779-782.
Bean L. J. H., Allen E. G., Tinker S. W. i in. (2011), Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: a report from the National Down Syndrome Project, Birth Defects Research, Part A: Clinical and Molecular Teratology, 91(10), 885-893.
Benkovic S. J. (1980), On the mechanism of action of folate and biopterin-requiring enzymes, Annual Review of Biochemistry, 49, 227-251.
Berg M. J. (1999), The importance of folic acid, Journal of Gender Specific Medicine, 2, 24-28.
Bomba-Opoń D., Hirnle L., Kalinka J., Seremak-Mrozikiewicz A. (2017), Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines, Ginekologia Polska, 88 (11), 633-636.
Chango A., Boisson F., Barbe F. (2000), The effect of 677C/T nad 1289 A/C mutation on plasma homocysteine nad 5,10-methylenetetrahydrotefolate reductase, British Journal of Nutrition, 83, 593-596.
Zmodyfikowano na podstawie: Czeczot H. (2008), Kwas foliowy w fizjologii
i patologii, Postępy Higieny i Medycyny Doświadczalnej, 62, 405-419.
Gregory J. F. III. (2001), Case study: folate bioavailability, The Journal of Nutrition, 131, 1376S-1382S.
Kauwell G. P., Wilsky C. E., Cerda J. J., Herrlinger-Garcia K., Hutson A. D., Theriaque D.W., Boddie A., Rampersaud G. C., Bailey L. B. (2000), Methylenetetrahydrofolate reductase mutation (677C>T) negatively influences plasma homocysteine response to marginal folate inatake in elderly woman, Metabolism, 49, 1440-1443.
Kim Y. I. (2000), Does a high folate intake increase the risk of breast cancer?, Nutrition Reviews., 64, 468-475.
Kim Y. I. (20040, Will mandatory folic acid fortifi cation prevent or promote cancer?, The American Journal of Clinical Nutrition, 80, 1123-1128.
Kozłowska-Wojciechowska M. (2005), Jak zapobiegać hiperhomocysteinemii? Naturalne źródła folianów i witamin z grupy B w polskiej diecie, Czynniki Ryzyka, 11, 25-26.
Lewis C. J., Crane N. T., Wilson D. B., Yetley E. A. (1990), Estimated folate intake: data updated to reflect food fortification, increased bioavailability and dietary supplement use, The American Journal of Clinical Nutrition, 70, 198-207. (PMID: 10426695, DOI: 10.1093/ajcn.70.2.198)
Li Z., Ye R., Zhang L., Li H., Liu J., Ren A. (2013), Folic acid supplementation during early pregnancy and the risk of gestational hypertension and preeclampsia, Hypertension, 61(4), 873–879.
Podolak-Dawidziak M. (2016) Interna Szczeklika. Kraków: Medycyna Praktyczna.
Prinz-Langenohl R., Brämswig S., Tobolski O. i in. (2009), (6S)-5-methylte-trahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C--> T polymorphism of methylenetetrahydrofolate reductase, British Journal of Pharmacology, 158(8), 2014-2021.
Refsum H. (2001), Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome, The British Journal of Nutrition, 85, S109-S113.
Richardson B. (2003), Impact of aging on DNA methylation. Ageing Research Reviews, 2, 245-261.
Rosenquist T. H., Ratashak S. A., Selhub J. (1996), Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid, Proceedings of the National Academy of Science, 93, 15227-15232.
Szczeklik A., Undas A. (2005), Homocysteina w żylnej chorobie zakrzepowo-zatorowej, Czynniki Ryzyka, supl. 11, 14-15.
Tsang B. L., Devine O. J., Cordero A. M. i in. (2015), Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies. The American Journal of Clinical Nutrition, 101(6), 1286-1294.
Ulrey C.L., Liu L., Andrews L.G., Tollefsbol T.O. (2005), The impact of metabolism on DNA methylation, Human Molecular Genetics, 14, R139-R147.
Wartanowicz M. (1997), Foliany w żywieniu (przegląd piśmiennictwa). Żywienie Człowieka i Metabolizm, 24, 81-90.
Wen S. W., Guo Y., Rodger M. i in. (2016), Folic Acid Supplementation in Pregnancy and the Risk of Pre-Eclampsia-A Cohort Study, PLOS One, 11(2): e0149818.
Wolski H., Kocięcka M., Mrozikiewicz A. E. i in. (2015), Coexistence of the 677C>T and 1298A>C MTHFR polymorphisms and its significance in the population of Polish women. Ginekologia Polska, 86(10), 742-747.
Yajnik C. S., Deshpande S. S., Jackson A. A. i in. (2008), Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study, Diabetologia, 51(1), 29-38.
Young I. S., Woodside J. V. (2000), Folate and homocysteine, Current Opinion in Clinical Nutrition and Metabolic Care, 3, 427-432.
Bailey L. B., Gregory J. F. (1999), Folate metabolism and requirements, The Journal of Nutrition, 129, 779-782.
Bean L. J. H., Allen E. G., Tinker S. W. i in. (2011), Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: a report from the National Down Syndrome Project, Birth Defects Research, Part A: Clinical and Molecular Teratology, 91(10), 885-893.
Benkovic S. J. (1980), On the mechanism of action of folate and biopterin-requiring enzymes, Annual Review of Biochemistry, 49, 227-251.
Berg M. J. (1999), The importance of folic acid, Journal of Gender Specific Medicine, 2, 24-28.
Bomba-Opoń D., Hirnle L., Kalinka J., Seremak-Mrozikiewicz A. (2017), Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines, Ginekologia Polska, 88 (11), 633-636.
Chango A., Boisson F., Barbe F. (2000), The effect of 677C/T nad 1289 A/C mutation on plasma homocysteine nad 5,10-methylenetetrahydrotefolate reductase, British Journal of Nutrition, 83, 593-596.
Zmodyfikowano na podstawie: Czeczot H. (2008), Kwas foliowy w fizjologii
i patologii, Postępy Higieny i Medycyny Doświadczalnej, 62, 405-419.
Gregory J. F. III. (2001), Case study: folate bioavailability, The Journal of Nutrition, 131, 1376S-1382S.
Kauwell G. P., Wilsky C. E., Cerda J. J., Herrlinger-Garcia K., Hutson A. D., Theriaque D.W., Boddie A., Rampersaud G. C., Bailey L. B. (2000), Methylenetetrahydrofolate reductase mutation (677C>T) negatively influences plasma homocysteine response to marginal folate inatake in elderly woman, Metabolism, 49, 1440-1443.
Kim Y. I. (2000), Does a high folate intake increase the risk of breast cancer?, Nutrition Reviews., 64, 468-475.
Kim Y. I. (20040, Will mandatory folic acid fortifi cation prevent or promote cancer?, The American Journal of Clinical Nutrition, 80, 1123-1128.
Kozłowska-Wojciechowska M. (2005), Jak zapobiegać hiperhomocysteinemii? Naturalne źródła folianów i witamin z grupy B w polskiej diecie, Czynniki Ryzyka, 11, 25-26.
Lewis C. J., Crane N. T., Wilson D. B., Yetley E. A. (1990), Estimated folate intake: data updated to reflect food fortification, increased bioavailability and dietary supplement use, The American Journal of Clinical Nutrition, 70, 198-207. (PMID: 10426695, DOI: 10.1093/ajcn.70.2.198)
Li Z., Ye R., Zhang L., Li H., Liu J., Ren A. (2013), Folic acid supplementation during early pregnancy and the risk of gestational hypertension and preeclampsia, Hypertension, 61(4), 873–879.
Podolak-Dawidziak M. (2016) Interna Szczeklika. Kraków: Medycyna Praktyczna.
Prinz-Langenohl R., Brämswig S., Tobolski O. i in. (2009), (6S)-5-methylte-trahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C--> T polymorphism of methylenetetrahydrofolate reductase, British Journal of Pharmacology, 158(8), 2014-2021.
Refsum H. (2001), Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome, The British Journal of Nutrition, 85, S109-S113.
Richardson B. (2003), Impact of aging on DNA methylation. Ageing Research Reviews, 2, 245-261.
Rosenquist T. H., Ratashak S. A., Selhub J. (1996), Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid, Proceedings of the National Academy of Science, 93, 15227-15232.
Szczeklik A., Undas A. (2005), Homocysteina w żylnej chorobie zakrzepowo-zatorowej, Czynniki Ryzyka, supl. 11, 14-15.
Tsang B. L., Devine O. J., Cordero A. M. i in. (2015), Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies. The American Journal of Clinical Nutrition, 101(6), 1286-1294.
Ulrey C.L., Liu L., Andrews L.G., Tollefsbol T.O. (2005), The impact of metabolism on DNA methylation, Human Molecular Genetics, 14, R139-R147.
Wartanowicz M. (1997), Foliany w żywieniu (przegląd piśmiennictwa). Żywienie Człowieka i Metabolizm, 24, 81-90.
Wen S. W., Guo Y., Rodger M. i in. (2016), Folic Acid Supplementation in Pregnancy and the Risk of Pre-Eclampsia-A Cohort Study, PLOS One, 11(2): e0149818.
Wolski H., Kocięcka M., Mrozikiewicz A. E. i in. (2015), Coexistence of the 677C>T and 1298A>C MTHFR polymorphisms and its significance in the population of Polish women. Ginekologia Polska, 86(10), 742-747.
Yajnik C. S., Deshpande S. S., Jackson A. A. i in. (2008), Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study, Diabetologia, 51(1), 29-38.
Young I. S., Woodside J. V. (2000), Folate and homocysteine, Current Opinion in Clinical Nutrition and Metabolic Care, 3, 427-432.
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