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Rabijewski, M. (2018). Endokrynologiczne przyczyny niepłodności u mężczyzn. Kwartalnik Naukowy Fides Et Ratio, 35(3), 176-189. Pobrano z https://fidesetratio.com.pl/ojs/index.php/FetR/article/view/547
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Wśród przyczyn zmniejszonej płodności u mężczyzn ważne miejsce zajmują genetyczne i nabyte zaburzenia endokrynologiczne. Pacjenci z wrodzonym hipogonadyzmem hipogonadotropowym (zespołem Kallmanna), zespołem Klinefeltera oraz innymi genetycznymi zaburzeniami osi podwzgórzowo-przysadkowo-gonadowej mają opóźnione dojrzewanie, hipogonadyzm oraz azoospermię i wymagają hormonalnej stymulacji dojrzewania, a później indukcji spermatogenezy lub technik wspomaganego rozrodu (zespół Klinefeltera). Zaburzenia spermatogenezy obserwujemy również u chorych z guzami lub chorobami zapalnymi podwzgórza i przysadki. Gruczolak przysadki wydzielający prolaktynę – prolactinoma, objawia się hipogonadyzmem, zaburzeniami wzwodu oraz zmniejszoną płodnością. Niekiedy zaburzenia płodności obserwujemy u chorych z tzw. czynnościowym hipogonadyzmem, związanym z otyłością, stresem, niedowagą lub nadmiernym wysiłkiem fizycznym oraz po stosowaniu sterydów anabolicznych. Pacjenci z wymienionymi chorobami endokrynologicznymi oraz z zaburzeniami czynności tarczycy nie zawsze mają upośledzoną spermatogenezę, ale często występuje hipoandrogenizm i zaburzenia wzwodu także ograniczające płodność u mężczyzn.
Bibliografia
Bakos H.W., Henshaw R.C., Mitchell M., Lane M. (2011), Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology, Fertility and Sterility, 95(5), 1700-1704.
Becker A. (1999), Eating Disorders, The New England Journal of Medicine, 341, 614-616.
Corona G., Rastrelli G., Reisman Y. i in. (2018), The safety of available treatments of male hypogonadism in organic and functional hypogonadism, Expert Opinion on Drug Safety, 17(3), 277-292.
Eisenberg M.L., Kim S., Chen Z. i in. (2014), The relationship between male BMI and waist circumference on semen quality: data from the LIFE study, Human Reproduction, 29(2), 193-200.
Gnoth C., Godehardt E., Frank-Herrmann P. i in (2005), Definition and prevalence of subfertility and infertility, Human Reproduction, 20(5), 1144-1147.
Kozakowski J., Dodek P. (2017), Impairment of male fertility – a consequential problem of our time. The impact of obesity and related metabolic disorders, Postępy Nauk Medycznych, 12, 674-678.
La Vignera S., Condorelli R.A., Vicari E., Calogero A.E. (2012), Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters, Journal of Andrology, 33(1), 53-58.
Laron Z., Karp M., Dolberg L. (1970), Juvenile hypothyroidism with testicular enlargement, Acta Paediatrica Scandinavica, 59, 317-322.
Liu P.Y., Baker H.W., Jayadev V. i in. (2009), Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome, The Journal of Clinical Endocrinology and Metabolism, 94(3), 801-808.
Meeker J.D., Godfrey-Bailey L., Hauser R. (2007), Relationships between serum hormone levels and semen quality among men from an infertility clinic, Journal of Andrology, 28(3), 397-406.
Nieschlag E. (2013), Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated, Deutsches Arzteblat International, 110(20), 347-53.
Palmert M.R., Dunkel L. (2012), Clinical practice. Delayed puberty, The New England Journal of Medicine, 366(5), 443-453.
Rabijewski M. (2011), Hipogonadyzm w mężczyzn, (w:) Endokrynologia, W. Zgliczyński (red.), Medical Tribune Polska.
Ramlau-Hansen C.H., Thulstrup A.M., Nohr E.A. i in. (2007), Subfecundity in overweight and obese couples, Human Reproduction, 22(6), 1634-1637.
Rastrelli G., Corona G., Mannucci E. i in. (2014), Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study, Andrology, 2(6), 794-808.
Resorlu B., Abdulmajed M.I., Kara C. i in. (2009), Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism?
A comparison between idiopathic and secondary hypogonadotrophic hypogonadism, Human Fertility, 12, 204-208.
Rohayem J., Nieschlag E. (2017), Stimulation of spermatogenesis in hypogonadal men,
(w:) Male hypogonadism, I.J. Winters, I.T. Huhtaniemi (red.), 423-436, Berlin: Springer.
Rojdmark S., Berg A., Kallner G. (1988), Hypothalamic-pituitary-testicular axis in patients with hyperthyroidism, Hormone Reserche, 29(5-6), 185-190.
Silveira L.F., MacColl G.S., Bouloux P.M. (2002), Hypogonadotropic hypogonadism, Seminars in Reproductive Medicine, 20(4), 327-338.
Silveira L.F., Trarbach E.B., Latronico A.C. (2010), Genetics basis for GnRH dependent pubertal disorders in humans, Molecular and Cellular Endocrinology, 324(1-2), 30-38.
Wajner S. M., Wagner M. S., Maia A. L. (2009), Clinical implications of altered thyroid status in male testicular function, Arq Bras Endocrinol Metabol, 53(8), 976-982.
Weinbauer G.cF., Luetjens C.cM., Simoni M. i in. (2010), Physiology of testicular function, w: Andrology: male reproductive health and dysfunctions, red. Nieschlag E., Behre H. M., Nieschlag S., Springer, Berlin, 11-59.
Wortsman J., Rosner W., Dufau M.L. (1987), Abnormal testicular function inmen with primary hypothyroidism, The American Journal of Medicine, 82(2), 207-212.
Young J. (2012), Approach to the male patient with congenital hypogonadotropic hypogonadism, The Journal of Clinical Endocrinology and Metabolism, 97(3), 707-718.
Zgliczyński W., Witek P., Zdunowski P. (2011), Guzy przysadki. Prolaktynoma i hiperprolaktynemia, w: Wielka Interna. Endokrynologia. Część I, A. Antczak,
M. Myśliwiec, P. Pruszczyk (red.), 67-74, Tom 11, Wyd. I. Medical Tribune.
Becker A. (1999), Eating Disorders, The New England Journal of Medicine, 341, 614-616.
Corona G., Rastrelli G., Reisman Y. i in. (2018), The safety of available treatments of male hypogonadism in organic and functional hypogonadism, Expert Opinion on Drug Safety, 17(3), 277-292.
Eisenberg M.L., Kim S., Chen Z. i in. (2014), The relationship between male BMI and waist circumference on semen quality: data from the LIFE study, Human Reproduction, 29(2), 193-200.
Gnoth C., Godehardt E., Frank-Herrmann P. i in (2005), Definition and prevalence of subfertility and infertility, Human Reproduction, 20(5), 1144-1147.
Kozakowski J., Dodek P. (2017), Impairment of male fertility – a consequential problem of our time. The impact of obesity and related metabolic disorders, Postępy Nauk Medycznych, 12, 674-678.
La Vignera S., Condorelli R.A., Vicari E., Calogero A.E. (2012), Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters, Journal of Andrology, 33(1), 53-58.
Laron Z., Karp M., Dolberg L. (1970), Juvenile hypothyroidism with testicular enlargement, Acta Paediatrica Scandinavica, 59, 317-322.
Liu P.Y., Baker H.W., Jayadev V. i in. (2009), Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome, The Journal of Clinical Endocrinology and Metabolism, 94(3), 801-808.
Meeker J.D., Godfrey-Bailey L., Hauser R. (2007), Relationships between serum hormone levels and semen quality among men from an infertility clinic, Journal of Andrology, 28(3), 397-406.
Nieschlag E. (2013), Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated, Deutsches Arzteblat International, 110(20), 347-53.
Palmert M.R., Dunkel L. (2012), Clinical practice. Delayed puberty, The New England Journal of Medicine, 366(5), 443-453.
Rabijewski M. (2011), Hipogonadyzm w mężczyzn, (w:) Endokrynologia, W. Zgliczyński (red.), Medical Tribune Polska.
Ramlau-Hansen C.H., Thulstrup A.M., Nohr E.A. i in. (2007), Subfecundity in overweight and obese couples, Human Reproduction, 22(6), 1634-1637.
Rastrelli G., Corona G., Mannucci E. i in. (2014), Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study, Andrology, 2(6), 794-808.
Resorlu B., Abdulmajed M.I., Kara C. i in. (2009), Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism?
A comparison between idiopathic and secondary hypogonadotrophic hypogonadism, Human Fertility, 12, 204-208.
Rohayem J., Nieschlag E. (2017), Stimulation of spermatogenesis in hypogonadal men,
(w:) Male hypogonadism, I.J. Winters, I.T. Huhtaniemi (red.), 423-436, Berlin: Springer.
Rojdmark S., Berg A., Kallner G. (1988), Hypothalamic-pituitary-testicular axis in patients with hyperthyroidism, Hormone Reserche, 29(5-6), 185-190.
Silveira L.F., MacColl G.S., Bouloux P.M. (2002), Hypogonadotropic hypogonadism, Seminars in Reproductive Medicine, 20(4), 327-338.
Silveira L.F., Trarbach E.B., Latronico A.C. (2010), Genetics basis for GnRH dependent pubertal disorders in humans, Molecular and Cellular Endocrinology, 324(1-2), 30-38.
Wajner S. M., Wagner M. S., Maia A. L. (2009), Clinical implications of altered thyroid status in male testicular function, Arq Bras Endocrinol Metabol, 53(8), 976-982.
Weinbauer G.cF., Luetjens C.cM., Simoni M. i in. (2010), Physiology of testicular function, w: Andrology: male reproductive health and dysfunctions, red. Nieschlag E., Behre H. M., Nieschlag S., Springer, Berlin, 11-59.
Wortsman J., Rosner W., Dufau M.L. (1987), Abnormal testicular function inmen with primary hypothyroidism, The American Journal of Medicine, 82(2), 207-212.
Young J. (2012), Approach to the male patient with congenital hypogonadotropic hypogonadism, The Journal of Clinical Endocrinology and Metabolism, 97(3), 707-718.
Zgliczyński W., Witek P., Zdunowski P. (2011), Guzy przysadki. Prolaktynoma i hiperprolaktynemia, w: Wielka Interna. Endokrynologia. Część I, A. Antczak,
M. Myśliwiec, P. Pruszczyk (red.), 67-74, Tom 11, Wyd. I. Medical Tribune.
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