How to Cite
Rabijewski, M. (2018). Endocrine causes of infertility in men . Quarterly Journal Fides Et Ratio, 35(3), 176-189. Retrieved from https://fidesetratio.com.pl/ojs/index.php/FetR/article/view/547
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Abstract
Impairment of fertility is a growing health problem. It should be always considered in relation to both partners, as it affects to a similar extent women and men. Proper development and function of male and female reproductive organs, the processes of egg cell and sperma formation and development as well as of conception and pregnancy maintenance depend on interaction of a number of factors, including hormones. Functioning of ovaries and testes is closely related to the activity of other endocrine glands. Therefore, infertility can be the result of a malfunction of the pituitary, thyroid or adrenals. The article discusses the most common causes of primary hypogonadism as well as hypothalamic and pituitary dysfunctions leading to hypogonadism, in particular gonadotropin deficiency and hyperprolactinemia. Special attention was paid to the endocrine effects of eating disorders, which result in impaired fertility. We also discussed the impact on fertility of the thyroid and adrenal diseases.
References
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Becker A. (1999), Eating Disorders, The New England Journal of Medicine, 341, 614-616.
Corona G., Rastrelli G., Reisman Y. i in. (2018), The safety of available treatments of male hypogonadism in organic and functional hypogonadism, Expert Opinion on Drug Safety, 17(3), 277-292.
Eisenberg M.L., Kim S., Chen Z. i in. (2014), The relationship between male BMI and waist circumference on semen quality: data from the LIFE study, Human Reproduction, 29(2), 193-200.
Gnoth C., Godehardt E., Frank-Herrmann P. i in (2005), Definition and prevalence of subfertility and infertility, Human Reproduction, 20(5), 1144-1147.
Kozakowski J., Dodek P. (2017), Impairment of male fertility – a consequential problem of our time. The impact of obesity and related metabolic disorders, Postępy Nauk Medycznych, 12, 674-678.
La Vignera S., Condorelli R.A., Vicari E., Calogero A.E. (2012), Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters, Journal of Andrology, 33(1), 53-58.
Laron Z., Karp M., Dolberg L. (1970), Juvenile hypothyroidism with testicular enlargement, Acta Paediatrica Scandinavica, 59, 317-322.
Liu P.Y., Baker H.W., Jayadev V. i in. (2009), Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome, The Journal of Clinical Endocrinology and Metabolism, 94(3), 801-808.
Meeker J.D., Godfrey-Bailey L., Hauser R. (2007), Relationships between serum hormone levels and semen quality among men from an infertility clinic, Journal of Andrology, 28(3), 397-406.
Nieschlag E. (2013), Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated, Deutsches Arzteblat International, 110(20), 347-53.
Palmert M.R., Dunkel L. (2012), Clinical practice. Delayed puberty, The New England Journal of Medicine, 366(5), 443-453.
Rabijewski M. (2011), Hipogonadyzm w mężczyzn, (w:) Endokrynologia, W. Zgliczyński (red.), Medical Tribune Polska.
Ramlau-Hansen C.H., Thulstrup A.M., Nohr E.A. i in. (2007), Subfecundity in overweight and obese couples, Human Reproduction, 22(6), 1634-1637.
Rastrelli G., Corona G., Mannucci E. i in. (2014), Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study, Andrology, 2(6), 794-808.
Resorlu B., Abdulmajed M.I., Kara C. i in. (2009), Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism?
A comparison between idiopathic and secondary hypogonadotrophic hypogonadism, Human Fertility, 12, 204-208.
Rohayem J., Nieschlag E. (2017), Stimulation of spermatogenesis in hypogonadal men,
(w:) Male hypogonadism, I.J. Winters, I.T. Huhtaniemi (red.), 423-436, Berlin: Springer.
Rojdmark S., Berg A., Kallner G. (1988), Hypothalamic-pituitary-testicular axis in patients with hyperthyroidism, Hormone Reserche, 29(5-6), 185-190.
Silveira L.F., MacColl G.S., Bouloux P.M. (2002), Hypogonadotropic hypogonadism, Seminars in Reproductive Medicine, 20(4), 327-338.
Silveira L.F., Trarbach E.B., Latronico A.C. (2010), Genetics basis for GnRH dependent pubertal disorders in humans, Molecular and Cellular Endocrinology, 324(1-2), 30-38.
Wajner S. M., Wagner M. S., Maia A. L. (2009), Clinical implications of altered thyroid status in male testicular function, Arq Bras Endocrinol Metabol, 53(8), 976-982.
Weinbauer G.cF., Luetjens C.cM., Simoni M. i in. (2010), Physiology of testicular function, w: Andrology: male reproductive health and dysfunctions, red. Nieschlag E., Behre H. M., Nieschlag S., Springer, Berlin, 11-59.
Wortsman J., Rosner W., Dufau M.L. (1987), Abnormal testicular function inmen with primary hypothyroidism, The American Journal of Medicine, 82(2), 207-212.
Young J. (2012), Approach to the male patient with congenital hypogonadotropic hypogonadism, The Journal of Clinical Endocrinology and Metabolism, 97(3), 707-718.
Zgliczyński W., Witek P., Zdunowski P. (2011), Guzy przysadki. Prolaktynoma i hiperprolaktynemia, w: Wielka Interna. Endokrynologia. Część I, A. Antczak,
M. Myśliwiec, P. Pruszczyk (red.), 67-74, Tom 11, Wyd. I. Medical Tribune.
Becker A. (1999), Eating Disorders, The New England Journal of Medicine, 341, 614-616.
Corona G., Rastrelli G., Reisman Y. i in. (2018), The safety of available treatments of male hypogonadism in organic and functional hypogonadism, Expert Opinion on Drug Safety, 17(3), 277-292.
Eisenberg M.L., Kim S., Chen Z. i in. (2014), The relationship between male BMI and waist circumference on semen quality: data from the LIFE study, Human Reproduction, 29(2), 193-200.
Gnoth C., Godehardt E., Frank-Herrmann P. i in (2005), Definition and prevalence of subfertility and infertility, Human Reproduction, 20(5), 1144-1147.
Kozakowski J., Dodek P. (2017), Impairment of male fertility – a consequential problem of our time. The impact of obesity and related metabolic disorders, Postępy Nauk Medycznych, 12, 674-678.
La Vignera S., Condorelli R.A., Vicari E., Calogero A.E. (2012), Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters, Journal of Andrology, 33(1), 53-58.
Laron Z., Karp M., Dolberg L. (1970), Juvenile hypothyroidism with testicular enlargement, Acta Paediatrica Scandinavica, 59, 317-322.
Liu P.Y., Baker H.W., Jayadev V. i in. (2009), Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome, The Journal of Clinical Endocrinology and Metabolism, 94(3), 801-808.
Meeker J.D., Godfrey-Bailey L., Hauser R. (2007), Relationships between serum hormone levels and semen quality among men from an infertility clinic, Journal of Andrology, 28(3), 397-406.
Nieschlag E. (2013), Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated, Deutsches Arzteblat International, 110(20), 347-53.
Palmert M.R., Dunkel L. (2012), Clinical practice. Delayed puberty, The New England Journal of Medicine, 366(5), 443-453.
Rabijewski M. (2011), Hipogonadyzm w mężczyzn, (w:) Endokrynologia, W. Zgliczyński (red.), Medical Tribune Polska.
Ramlau-Hansen C.H., Thulstrup A.M., Nohr E.A. i in. (2007), Subfecundity in overweight and obese couples, Human Reproduction, 22(6), 1634-1637.
Rastrelli G., Corona G., Mannucci E. i in. (2014), Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study, Andrology, 2(6), 794-808.
Resorlu B., Abdulmajed M.I., Kara C. i in. (2009), Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism?
A comparison between idiopathic and secondary hypogonadotrophic hypogonadism, Human Fertility, 12, 204-208.
Rohayem J., Nieschlag E. (2017), Stimulation of spermatogenesis in hypogonadal men,
(w:) Male hypogonadism, I.J. Winters, I.T. Huhtaniemi (red.), 423-436, Berlin: Springer.
Rojdmark S., Berg A., Kallner G. (1988), Hypothalamic-pituitary-testicular axis in patients with hyperthyroidism, Hormone Reserche, 29(5-6), 185-190.
Silveira L.F., MacColl G.S., Bouloux P.M. (2002), Hypogonadotropic hypogonadism, Seminars in Reproductive Medicine, 20(4), 327-338.
Silveira L.F., Trarbach E.B., Latronico A.C. (2010), Genetics basis for GnRH dependent pubertal disorders in humans, Molecular and Cellular Endocrinology, 324(1-2), 30-38.
Wajner S. M., Wagner M. S., Maia A. L. (2009), Clinical implications of altered thyroid status in male testicular function, Arq Bras Endocrinol Metabol, 53(8), 976-982.
Weinbauer G.cF., Luetjens C.cM., Simoni M. i in. (2010), Physiology of testicular function, w: Andrology: male reproductive health and dysfunctions, red. Nieschlag E., Behre H. M., Nieschlag S., Springer, Berlin, 11-59.
Wortsman J., Rosner W., Dufau M.L. (1987), Abnormal testicular function inmen with primary hypothyroidism, The American Journal of Medicine, 82(2), 207-212.
Young J. (2012), Approach to the male patient with congenital hypogonadotropic hypogonadism, The Journal of Clinical Endocrinology and Metabolism, 97(3), 707-718.
Zgliczyński W., Witek P., Zdunowski P. (2011), Guzy przysadki. Prolaktynoma i hiperprolaktynemia, w: Wielka Interna. Endokrynologia. Część I, A. Antczak,
M. Myśliwiec, P. Pruszczyk (red.), 67-74, Tom 11, Wyd. I. Medical Tribune.
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